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How might metformin exert its mysterious effects in both diabetes and cancer? In 2001, Zhou and colleagues found that metformin indirectly activates AMP kinase, a.MA.32 Metformin A phase III randomized trial of metformin versus placebo on recurrence and survival in early stage breast cancer. Identifier.

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Metformin is also frequently described as an insulin sensitizer leading to reduction in insulin resistance and significant reduction of plasma fasting insulin.

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